Guy drinks last of wine (5)
I believe the answer is:
tease
'guy' is the definition.
(I've seen this before)
'drinks last of wine' is the wordplay.
'drinks' becomes 'teas' (tea is a kind of drink).
'last of' indicates one should take the final letters.
The final letter of 'wine' is 'e'.
'teas'+'e'='TEASE'
(Other definitions for tease that I've seen before include "cause some irritation" , "Josh" , "Twit - flirt" , "Banter, make gentle fun of" , "Torment for fun" .)