Guy hemming edges of Everton strip (6)
I believe the answer is:
denude
'strip' is the definition.
(synonyms)
'guy hemming edges of everton' is the wordplay.
'guy' becomes 'dude' (both can informally mean a man).
'hemming' indicates putting letters inside (hem can mean to enclose).
'edges of' suggests removing the centre.
'everton' with its middle removed is 'en'.
'dude' placed around 'en' is 'DENUDE'.
(Other definitions for denude that I've seen before include "Put off covering" , "Strip - expose" , "Strip cover from, as leaves from trees" , "Lay bare" , "Dundee (anag.)" .)