Guy I remedy with a treatment for his hands (8)
I believe the answer is:
manicure
'a treatment for his hands' is the definition.
Although both the answer and definition are singular nouns, I cannot see how one could define the other.
'guy i remedy' is the wordplay.
'guy' becomes 'man' (guy can informally mean a man).
'remedy' becomes 'cure' (synonyms).
'man'+'i'+'cure'='MANICURE'
'with' acts as a link.
Can you help me to learn more?
(Other definitions for manicure that I've seen before include "Cosmetic care of the hands" , "attention to extremities" , "Work on nails" , "Hand and nail treatment" , "Professional hand treatment" .)