Heading off anguish, time running out for complaint (7*)
I believe the answer is:
Here is my best explanation:
'heading off anguish time running' is the definition.
I can't tell whether this definition defines the answer.
'out for complaint' is the subsidiary indication.
'out' becomes 'ear' (I can't justify this - if you can you should give a lot more credence to this answer).
'for' is a charade indicator (letters next to each other).
'complaint' becomes 'ache'.
(Other definitions for earache that I've seen before include "Pain for listener", "Pain inside the head", "Otic pain", "A complaint", "complaint to The Listener", "Pain in aural organ", "Ace hare (anag.)", "Incessant complaining", "Each era (anag)" and "a problem for some listeners".)