Her sin is to spoil a holy place (6)
I believe the answer is:
shrine
'a holy place' is the definition.
(holy site dedicated to a particular person)
'her sin is to spoil' is the wordplay.
'is to spoil' indicates anagramming the letters.
'her'+'sin'='hersin'
'hersin' anagrammed gives 'SHRINE'.
(Other definitions for shrine that I've seen before include "Place of worship associated with a revered person" , "Container for sacred relics" , "Casket with holy relics" , "Pilgrim's destination" , "here to pray?" .)