Hold up a new deal with a Yankee (5)
I believe the answer is:
delay
'hold up' is the definition.
(I know that hold up can be written as delay)
'a new deal with a yankee' is the wordplay.
'a new' indicates an anagram.
'with' means one lot of letters go next to another.
'a yankee' becomes 'y' (phonetic alphabet: alpha, bravo, charlie etc.).
'deal' with letters rearranged gives 'dela'.
'dela'+'y'='DELAY'
(Other definitions for delay that I've seen before include "Time lapse" , "Put off until later" , "Defer; make late" , "Procrastinate - put off" , "Linger - slow down - put off" .)