Horn of insect, large on queen (6)
I believe the answer is:
antler
'horn' is the definition.
(I know that antler is a type of horn)
'insect large on queen' is the wordplay.
'insect' becomes 'ant' (ant is a kind of insect).
'large' becomes 'L' (eg in clothes sizes).
'on' says to put letters next to each other.
'queen' becomes 'ER' (abbreviation for Elizabeth Regina).
'ant'+'l'+'er'='ANTLER'
'of' is the link.
(Other definitions for antler that I've seen before include "One on stag's head" , "Part of a deer" , "Deer-horn" , "Horn maybe of 24" , "Branched horn of deer" .)