Husband with restless desire a hindrance (5)
I believe the answer is:
hitch
'a hindrance' is the definition.
(I know that hindrance can be written as hitch)
'husband with restless desire' is the wordplay.
'husband' becomes 'h'.
'with' is a charade indicator (letters next to each other).
'restless desire' becomes 'itch' (as in having an itch for something).
'h'+'itch'='HITCH'
(Other definitions for hitch that I've seen before include "Setback" , "Technical problem" , "Snag; tie up (animal)" , "Snag - free ride" , "unite" .)