Imagist set off in disgrace (10)
I believe the answer is:
stigmatise
'disgrace' is the definition.
(stigmatise can mean to treat as a disgrace)
'imagist set off' is the wordplay.
'off' indicates anagramming the letters.
'imagist'+'set'='imagistset'
'imagistset' anagrammed gives 'STIGMATISE'.
'in' acts as a link.
(Other definitions for stigmatise that I've seen before include "Mark with disgrace" , "Regard as worthy of disgrace" .)