In operation (7)
(Other definitions for up and running that I've seen before include "working properly" , "Fully functional" , "Already active" , "like a jogger first thing?" , "like the early morning athlete" .)
'in operation' is the definition.
(I've seen this before)
This is all the clue.
(Other definitions for running that I've seen before include "Directing" , "No chance if you're out of it" , "healthy activity?" , "cross-country event?" , "Management" .)