In spite of everything (10)

I think it could be either:

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5,3

after all

'in spite of everything' is the definition.
(I've seen this before)

This is the entire clue.

(Other definitions for after all that I've seen before include "Taking everything into account" , "In spite of any indications to the contrary" , "when push comes to shove" , "Behind from start to finish" , "I mean, when everything's said and done" .)

I've seen this clue in The Independent, the Evening Standard, The Mirror, The Guardian, The Sun, The Telegraph and The Times.

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