In use can turn into a problem (8)
I believe the answer is:
nuisance
'a problem' is the definition.
(thesaurus)
'in use can turn' is the wordplay.
'turn' is an anagram indicator.
'in'+'use'+'can'='inusecan'
'inusecan' with letters rearranged gives 'NUISANCE'.
'into' is the link.
(Other definitions for nuisance that I've seen before include "Source of annoyance or aggravation" , "Trouble" , "One causing annoyance" , "'Pest, annoyance (8)'" , "It causes inconvenience or annoyance" .)