Is able to accommodate large family (4)
I believe the answer is:
clan
'family' is the definition.
(clan can mean a large family)
'is able to accommodate large' is the wordplay.
'is able' becomes 'can' (if you can do something, you are able to do it).
'to accommodate' indicates putting letters inside.
'large' becomes 'L' (eg in clothes sizes).
'can' placed around 'l' is 'CLAN'.
(Other definitions for clan that I've seen before include "Group with common ancestor, like the Campbells" , "Large family forming close group, big in Scotland" , "Highland grouping" , "Tribal group with common ancestor" , "Group of related families" .)