Is little Susan having children? (5)
I believe the answer is:
issue
'children?' is the definition.
(issue can mean someone's offspring)
'is little susan' is the wordplay.
'little susan' becomes 'sue' (I've seen this before).
'is'+'sue'='ISSUE'
'having' is the link.
(Other definitions for issue that I've seen before include "Children, edition" , "Matter of contention" , "Argument" , "Put out; result" , "Give out; children" .)