Issue, with great caution, a collection of numbers (8)
I believe the answer is:
songbook
'a collection of numbers' is the definition.
(collection of musical numbers)
'issue with great caution' is the wordplay.
'issue' becomes 'son' (issue can mean someone's offspring).
'with' is a charade indicator (letters next to each other).
'great' becomes 'g' (abbreviation in place names).
'caution' becomes 'book' (a footballer receiving a yellow card gets 'booked').
'son'+'g'+'book'='SONGBOOK'
(Other definitions for songbook that I've seen before include "More than one score from this" , "Collection of vocal pieces" , "Collection of music" , "Volume containing lyrics, hymns, etc" , "musical collection" .)