It makes a change from Salerno (7)
I believe the answer is:
orleans
'it makes a change' is the definition.
The definition suggests a singular noun which matches the answer.
'from salerno' is the wordplay.
'from' indicates anagramming the letters (from the letters).
'salerno' is an anagram of 'ORLEANS'.
Can you help me to learn more?
(Other definitions for orleans that I've seen before include "French city saved by Joan of Arc" , "French city on the Loire" , "Joan of Arc was known as the Maid of . . . . . . ." , "historic French city" , "material" .)