It makes dog run into the earth (6)
I believe the answer is:
ground
'the earth' is the definition.
(synonyms)
'it makes dog run' is the wordplay.
'it makes' is an anagram indicator.
'dog'+'run'='dogrun'
'dogrun' is an anagram of 'GROUND'.
'into' acts as a link.
(Other definitions for ground that I've seen before include "Worked hard" , "The solid surface of the Earth" , "Stadium; crushed" , "on which Pachelbel wrote his Canon?" , "Stop (a pilot) flying" .)