Crossword Genius

Italian region known for spumante (4)

Ross

I believe the answer is:

asti

(Other definitions for asti that I've seen before include "Sparkling white wine" , "Italian wine - (then change a letter for ...)" , "Italian town, famous for its wine" , "Source of fizz" , "Sparkling drink" .)

I've seen this clue in the Universal.
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