Joint enterprise finally getting large yield (5)
I believe the answer is:
elbow
'joint' is the definition.
(joint of the body)
'enterprise finally getting large yield' is the wordplay.
'finally' suggests the final letters.
'getting' means one lot of letters go next to another.
'large' becomes 'L' (eg in clothes sizes).
'yield' becomes 'bow' (bowing is a kind of yielding).
The last letter of 'enterprise' is 'e'.
'e'+'l'+'bow'='ELBOW'
(Other definitions for elbow that I've seen before include "Sharp bend in a road or river" , "given to one about to leave" , "Below (anag.)" , "sharp turn" , "push" .)