Last word from heavy-hearted chaps (4)
I believe the answer is:
amen
'last word' is the definition.
(last word in a prayer)
'heavy-hearted chaps' is the wordplay.
'hearted' says to take the centre.
'chaps' becomes 'men' (chap means a man).
The middle letter of 'heavy' is 'a'.
'a'+'men'='AMEN'
'from' acts as a link.
(Other definitions for amen that I've seen before include "Conclusion of prayer" , "Prayer ending" , "Name for end to prayer" , "I agree!" , "Final word in prayer" .)