Leader of police stops mastermind leaving home? He made many busts (7)
I believe the answer is:
epstein
'he made many busts' is the definition.
(sculptor Jacob Epstein made many busts)
'leader of police stops mastermind leaving home?' is the wordplay.
'leader of police' becomes 'p' (I can't justify this - if you can you should give a lot more credence to this answer).
'stops' is an insertion indicator (stopping can mean blocking a gap).
'mastermind' becomes 'Einstein' (Albert Einstein).
'leaving' is a deletion indicator.
'home?' becomes 'in' ('he's home' can mean 'he's in').
'einstein' with 'in' taken away is 'estein'.
'p' put inside 'estein' is 'EPSTEIN'.
(Other definitions for epstein that I've seen before include "Brian --, Beatles manager" , "Sir Jacob --, US-born British sculptor" , "American-born British sculptor, d. 1959" , "A rock band manager" , "British sculptor, d. 1959 - Beatles manager, d. 1967" .)