Leader of Republic deposed, creating anger (3)

I believe the answer is:

ire

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'anger' is the definition.
(ire is intense rage)

I cannot understand how the rest of the clue works.

(Other definitions for ire that I've seen before include "Strong emotion" , "'Anger, wrath (3)'" , "exasperation" , "Intense anger" , "Fury" .)

I've seen this clue in The Times.

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