Left one’s home in the East End abandoned (8)
I believe the answer is:
lonesome
'abandoned' is the definition.
(I've seen this before)
'left one's home in the east end' is the wordplay.
'left' becomes 'l' (common abbreviation).
'in the east end' means to remove the first letter (drop a letter, as a cockney might).
'home' with its initial letter taken off is 'ome'.
'l'+'ones'+'ome'='LONESOME'
(Other definitions for lonesome that I've seen before include "On one's own" , "Isolated" , "Solitary (mainly US)" , "Loosen me, being solitary" , "Abandoned" .)