Little less difficult clue (9)
I believe the answer is:
minuscule
'little' is the definition.
(synonyms)
'less difficult clue' is the wordplay.
'less' becomes 'minus' (I've seen this before).
'difficult' indicates anagramming the letters.
'clue' anagrammed gives 'cule'.
'minus'+'cule'='MINUSCULE'
(Other definitions for minuscule that I've seen before include "Not important" , "unimportant" , "Extremely small, tiny" , "not capital" , "Fine" .)