Live and prosper, losing nothing (5)
I believe the answer is:
dwell
'live' is the definition.
(to live/dwell somewhere)
'prosper losing nothing' is the wordplay.
'prosper' becomes 'dowell' (I've seen this in another clue).
'losing' suggests deleting specific letters.
'nothing' becomes 'O' (looks like zero - 0).
'dowell' with 'o' taken out is 'DWELL'.
'and' is the link.
(Other definitions for dwell that I've seen before include "Settle" , "Harp" , "Inhabit" , "stay" , "Hang out" .)