Load the vehicle and leave (5)
I believe the answer is:
cargo
'load' is the definition.
(I know that load can be written as cargo)
'vehicle and leave' is the wordplay.
'vehicle' becomes 'car' (car is a kind of vehicle).
'and' is a charade indicator (letters next to each other).
'leave' becomes 'go' (to go is to depart or leave).
'car'+'go'='CARGO'
'the' acts as a link.
(Other definitions for cargo that I've seen before include "stuff to be carried by ship" , "What gets carried" , "Hold contents" , "Baggage" , "Goods carried by vessel or vehicle" .)