Lose heart as pride wounded (7)
I believe the answer is:
despair
'lose heart' is the definition.
(thesaurus)
'as pride wounded' is the wordplay.
'wounded' indicates an anagram.
'as'+'pride'='aspride'
'aspride' anagrammed gives 'DESPAIR'.
(Other definitions for despair that I've seen before include "A spider (anag.)" , "Resignation" , "Lose heart" , "Give up hope" , "displaying lack of optimism" .)