Lose hope (7)

I think it could be either:

despair

despond

'lose hope' is the definition.
(thesaurus)

This is all the clue.

(Other definitions for despond that I've seen before include "Its Slough, Bunyan" , "Become disheartened" .)

I've seen this clue in The Telegraph, the Sydney Morning Herald, The Independent, the Penny Press, The Star Tribune and the Evening Standard.

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