Loss of status connected with mission (10)
I believe the answer is:
relegation
'loss' is the definition.
The definition and answer can be both acts as well as being singular nouns.
Perhaps there's a link between them I don't understand?
'of status connected with mission' is the wordplay.
'of status' becomes 're' (I am not sure about this - if you are sure you should believe this answer much more).
'connected with' is a charade indicator (letters next to each other).
'mission' becomes 'legation' (legation is a kind of mission).
're'+'legation'='RELEGATION'
Can you help me to learn more?
(Other definitions for relegation that I've seen before include "that's going down" , "Transference to a lower league" , "Demotion, to a lower league" , "Lowering of status" .)