Mad dog with bile is bound (7)
I believe the answer is:
obliged
'is bound' is the definition.
(I've seen this before)
'mad dog with bile' is the wordplay.
'mad' indicates anagramming the letters.
'with' says to put letters next to each other.
'dog' put after 'bile' is 'biledog'.
'biledog' is an anagram of 'OBLIGED'.
(Other definitions for obliged that I've seen before include "Compelled by duty" , "Indebted" , "Bound by a favour rendered" , "Bound by duty or gratitude" , "Duty-bound" .)