Make again (4)
I believe the answer is:
redo
'make again' is the definition.
('do' is an answer for 'make' so perhaps 'redo' is OK for 'make again')
This is the entire clue.
(Other definitions for redo that I've seen before include "Start again" , "Carry out again" , "Make anew" , "Fashion again" , "Decorate (eg a room) again" .)