Make issue for tablet in box (9)
I believe the answer is:
procreate
'make' is the definition.
(procreating is a kind of making)
'for tablet in box' is the wordplay.
'for' becomes 'pro' (as in being 'pro' something).
'tablet' becomes 'e' (E can mean ecstasy or an ecstasy tablet).
'in' indicates putting letters inside.
'box' becomes 'crate' (crate is a kind of box).
'e' going inside 'crate' is 'create'.
'pro'+'create'='PROCREATE'
'issue' is the link.
(Other definitions for procreate that I've seen before include "To be a breeder" , "father" , "Produce offspring" , "Get children" , "Make children" .)