Male and female desire to harm (6)
I believe the answer is:
malice
'desire to harm' is the definition.
I can't tell whether this definition defines the answer.
'male and female' is the wordplay.
'male' becomes 'm' (common abbreviation).
'and' says to put letters next to each other.
'female' becomes 'alice'.
'm'+'alice'='MALICE'
Can you help me to learn more?
(Other definitions for malice that I've seen before include "Hatred" , "Ill will, a desire to harm others" , "Malevolence, spite" , "evil intent" , "Desire to harm others, may be aforethought" .)