Man penning article is in discomfort (7)
I believe the answer is:
malaise
'discomfort' is the definition.
(I know that malaise is a type of discomfort)
'man penning article is' is the wordplay.
'man' becomes 'male' ().
'penning' is an insertion indicator.
'article' becomes 'a' (the indefinite article in English).
'a'+'is'='ais'
'male' enclosing 'ais' is 'MALAISE'.
'in' acts as a link.
(Other definitions for malaise that I've seen before include "Feeling of physical or mental illness" , "Feeling of impending illness" , "Disquiet" , "depression" , "Feeling of illness or mental uneasiness" .)