Messed-up fact-feed made a difference (8)
I believe the answer is:
affected
'made a difference' is the definition.
The definition and answer can be both related to bodily activities as well as being past participle verbs.
Maybe you can see a link between them that I can't see?
'messed-up fact-feed' is the wordplay.
'messed up' indicates an anagram.
'fact'+'feed'='factfeed'
'factfeed' anagrammed gives 'AFFECTED'.
Can you help me to learn more?
(Other definitions for affected that I've seen before include "attacked" , "False - unnatural" , "Artificial of manner, pretentious" , "Impacted on" , "Not natural" .)