Muse Clio playing stadium (8)
I believe the answer is:
coliseum
'stadium' is the definition.
(I know that coliseum is a type of stadium)
'muse clio playing' is the wordplay.
'playing' indicates anagramming the letters.
'muse'+'clio'='museclio'
'museclio' with letters rearranged gives 'COLISEUM'.
(Other definitions for coliseum that I've seen before include "Large venue" , "London theatre" , "Large amphitheatre" , "Large oval stadium with tiers of seats" , "large, entertaining building" .)