Nasty graze on Ned's hairy region (6,4)

I believe the answer is:

danger zone

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'hairy region' is the definition.
'danger zone' can be an answer for 'region' (danger zone is a kind of region). I'm not certain of the 'hairy' bit.

'nasty graze on ned's' is the wordplay.
'nasty' is an anagram indicator (a nasty or wrong spelling).
'graze'+'on'+'ned'='grazeonned'
'grazeonned' with letters rearranged gives 'DANGER ZONE'.

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