Nationwide misery having to accept failure (6)
I believe the answer is:
demise
'failure' is the definition.
(I've seen this in other clues)
'nationwide misery having to accept' is the wordplay.
'to accept' indicates the answer is hidden within the clue.
'DEMISE' is hidden in the letters of 'nationwide misery having'.
(Other definitions for demise that I've seen before include "Passing" , "Death or termination" , "Death, collapse" , "(Person's) death" , "Death or expiration" .)