Negative, sire - it's wrong to be more inquisitive (6)
I believe the answer is:
nosier
'be more inquisitive' is the definition.
(nosy means overly inquisitive or curious)
'negative sire it's wrong' is the wordplay.
'negative' becomes 'no' (no is a kind of negative).
'it's wrong' indicates anagramming the letters.
'sire' anagrammed gives 'sier'.
'no'+'sier'='NOSIER'
'to' is the link.
(Other definitions for nosier that I've seen before include "Senior (anag)" , "More inquisitive" , "More curious, being senior" , "More curious in nasal way" , "rather curious" .)