New priest in confusion (8)
I believe the answer is:
pristine
'new' is the definition.
(synonyms)
'priest in confusion' is the wordplay.
'confusion' indicates anagramming the letters.
'priest'+'in'='priestin'
'priestin' is an anagram of 'PRISTINE'.
(Other definitions for pristine that I've seen before include "Original, unspoiled" , "ancient" , "not spoiled" , "Virgin" , "Fresh and clean as if new" .)