Not against being free, independent, cold and hostile? (12)
I believe the answer is:
antagonistic
'hostile?' is the definition.
('antagonistic' can be similar in meaning to 'hostile')
'not against being free independent cold' is the wordplay.
'being free' indicates an anagram.
'independent' becomes 'i'.
'cold' becomes 'C' (abbreviation, eg on taps).
'not'+'against'='notagainst'
'notagainst' with letters rearranged gives 'antagonist'.
'antagonist'+'i'+'c'='ANTAGONISTIC'
'and' is the link.
(Other definitions for antagonistic that I've seen before include "Actively hostile" , "Actively opposing - stag in action (anag)" , "Ill-disposed" .)