Not the first weekend stuck in beer joint (5)
I believe the answer is:
ankle
'joint' is the definition.
(ankle is a kind of joint)
'not the first weekend stuck in beer' is the wordplay.
'the first' suggests taking the first letters.
'weekend' becomes 'k' (I've seen this in other clues).
'stuck in' means one lot of letters goes inside another.
'beer' becomes 'ale' (I've seen this before).
The initial letter of 'not' is 'n'.
'n'+'k'='nk'
'nk' inserted into 'ale' is 'ANKLE'.
(Other definitions for ankle that I've seen before include "Lower leg joint" , "Low joint" , "Leg-joint" , "Foot-leg connector" , "Joint between foot and leg" .)