Odd native with Eastern simplicity (7)
I believe the answer is:
naivete
'simplicity' is the definition.
(I've seen this before)
'odd native with eastern' is the wordplay.
'odd' indicates anagramming the letters.
'with' means one lot of letters goes inside another.
'eastern' becomes 'e'.
'native' anagrammed gives 'naivte'.
'naivte' going around 'e' is 'NAIVETE'.
(Other definitions for naivete that I've seen before include "lack of sophistication" , "Greenness" , "Ingenuousness" , "Innocence, artlessness" , "Quality of innocent gullibility" .)