Otto's making honey (5)
I believe the answer is:
toots
'honey' is the definition.
(I've seen this in another clue)
'otto's making' is the wordplay.
'making' indicates anagramming the letters.
'ottos' with letters rearranged gives 'TOOTS'.
(Other definitions for toots that I've seen before include "Honks horn" , "ducks" , "Florence Dombey's admirer" , "Beeps" , "gentle Dickensian" .)