Out of bed, drunk and highly-strung (7)
I believe the answer is:
uptight
'highly-strung' is the definition.
(I've seen this before)
'out of bed drunk' is the wordplay.
'out of bed' becomes 'up' ('up' can be a synonym of 'out of bed').
'drunk' becomes 'tight' (I've seen this in other clues).
'up'+'tight'='UPTIGHT'
'and' is the link.
(Other definitions for uptight that I've seen before include "Like a tense person" , "Irritated" , "Showing repressed anxiety or anger" , "Repressed and disapproving" , "Tense, nervous, repressed" .)