Pain in the neck (5)
(Other definitions for nuisance that I've seen before include "See 16" , "Annoying thing/person" , "Tiresome person or event" , "Source of irritation, person or thing" , "Bothersome pest" .)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">pain in the neck</span>' is the definition.<br/ ><span class="explanation-format__explanation">(irritant is a kind of pain in the neck)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for irritant that I've seen before include "Cause of itch" , "Source of continual annoyance" , "Annoying thing" , "Something that chafes or annoys" , "distraction" .)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">pain in the neck</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I've seen this in another clue)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for crick that I've seen before include "Wrench (neck or back)" , "Muscle spasm in the neck" , "Pain in the neck" , "Neck injury" , "Sort of cramp" .)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">pain in the neck</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for annoyance that I've seen before include "Irritation, vexation" , "Feeling of slight anger" , "(Anger at) harassment" , "trouble" , "Source of anger" .)