People to lose millions plugging dry red wine (4)
I believe the answer is:
tent
'red wine' is the definition.
(type of Spanish wine)
'people to lose millions plugging dry' is the wordplay.
'people' becomes 'men' (men are people).
'to lose' indicates named letters should be taken away.
'millions' becomes 'm' (abbreviation).
'plugging' indicates putting letters inside (I've seen this in other clues).
'dry' becomes 'tt' (short for teetotal - no alcohol).
'men' with 'm' taken out is 'en'.
'en' inserted into 'tt' is 'TENT'.
(Other definitions for tent that I've seen before include "Canvas shelter; wine" , "Bivvy" , "Portable shelter - red wine" , "Camping shelter" , "Portable shelter for camper" .)