Pick up head of lettuce to take home (5)
I believe the answer is:
learn
'pick up' is the definition.
('learn' can be a synonym of 'pick up')
'head of lettuce to take home' is the wordplay.
'head of' suggests taking the first letters.
'to take home' becomes 'earn' (I've seen this before).
The first letter of 'lettuce' is 'l'.
'l'+'earn'='LEARN'
(Other definitions for learn that I've seen before include "Con" , "Be educated" , "Get to know" , "Acquire information" , "Acquire knowledge or skill" .)