Play around with an instrument (6)
I believe the answer is:
fiddle
This clue is a double definition.
'play around' is the first definition.
(thesaurus)
'an instrument' is the second definition.
(fiddle is a kind of instrument)
'with' acts as a link.
(Other definitions for fiddle that I've seen before include "Bowed stringed instrument" , "Awkward task" , "Deception" , "Kit perhaps" , "Swindle with informal violin" .)