Play with great guy on island (3,3,8)
I believe the answer is:
man and superman
Here is my best explanation:
'play' is the definition.
(I've seen this before)
'with great guy on island' is the subsidiary indication.
'with' becomes 'and' (I've seen this before).
'great guy' becomes 'superman' (I've seen this before).
'on' says to put letters next to each other.
'island' becomes 'man' (Man is an example).
'andsuperman' after 'man' is 'manandsuperman'.
(Other definitions for man and superman that I've seen before include "Play by George Bernard Shaw" and "play".)